synthesis of some novel chromenopyrimidine derivatives and evaluation of their biological activities

نویسندگان

akbar mobinikhaledi arak university- org. chem

naser foroughifar azad university/arak university

tahere mosleh arak university

ahmad hamta arak university/biology dept

چکیده

abstractpyrimidine nucleosides are constituents of fundamental structure of the cells. there has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensivity and anti-convulsant agents. as a part of our research work in the synthesis of pyrimidines containing biological activities, a series of chromenopyrimidine derivatives were synthesized by reaction of an intermediate imine and ammonia derivatives in good to high yields. all synthesized compounds were characterized using ir and nmr (1h and 13c) spectroscopy and elemental analysis data. the antibacterial activity of these compounds was investigated against staphylococcus aureus (rtcc, 1885), and escherichia coli (atcc, 35922).

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Synthesis of some Novel Chromenopyrimidine Derivatives and Evaluation of Their Biological Activities

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Synthesis of some Novel Chromenopyrimidine Derivatives and Evaluation of Their Biological Activities

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Synthesis of Some Novel Chromenopyrimidine Derivatives and Evaluation of Their Biological Activities

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۳، شماره ۳، صفحات ۸۷۳-۸۷۹

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